尿激酶溶解兔脑内血肿的实验研究

LYSIS OF INTRACEREBRAL HEMATOMAS WITH UROKINASE IN RABBITS

作者以尿激酶(10000～20000IU/ml,0.2ml)注入兔脑右顶叶实质,发现注药前后凝血酶原时间无显著差异,兔行为无改变,脑组织无出血或坏死。然后取27只新西兰兔,于右顶叶注入0.2ml血块,其中18只即刻在血块内注入10000IU/ml尿激酶0.2ml,对照组9只注入0.2ml生理盐水。3小时后治疗组9只中6只血块溶解,对照组3只均未溶解(P<0.05);24小时后,治疗组9只中7只溶解,对照组6只中1只溶解(P<0.05)。病理切片示治疗组血肿周围脑实质的水肿程度和退行性改变较对照组为轻。

0.2ml of urokinase (UK) (2000-4000IU) was injected into the parenchyma of the right parietal lobe of rabbit's brain. The results showed that both the prothrombin time and the rabbit behaviour remained unchanged after injection, and pathologic examination of the brain tissue disclosed no hemorrhage or necrosis. Then 0.2ml blood clot was injected into the right parietal lobe in 27 rabbits. In 18 of them, 0.2 ml (2000 IU) of UK was immediately injected into the clot. The remained 9 rabbits were injected with 0.2 ml saline as controls. In the treatment group, 13 animals had their clots lyzed while in the control group only 1 clot was lyzed. Pathologic examination showed that edema and degeneration of the perihematoma parenchyma were less in the treatment group than in the controls. This experiment suggests that intracranial application of UK may be a safe and effective method for lyzing residual clots in cases of intracerebral hematoma.