黄体生成素释放激素自动微量脉冲输液泵诱发排卵

INDUCED OVULATION BY SUBCUTANEOUS PULSATILE ADMINISTRATION OF LH-RH

作者应用自行设计和研制的自动微量脉冲输液泵,采用国产黄体生成素释放激素(LHRH)皮下脉冲输注,治疗下丘脑性闭经和多囊卵巢综合征患者。给药方法为每隔90分钟释液50μl(含LH-RH15～20μg)1次,每次1分钟。1例下丘脑闭经经治疗后,于第1治疗周期即有排卵,血牢FSH、LH、E_2和孕酮等均达到正常水平。1例多囊综合征经治疗49天无效,行卵巢楔形切除术后2月,基础体温出现双相,排卵转经。文内对给药的剂量、频率和途径等进行了讨论。

LH-RH was administered by subcutaneous pulsatile infusion with micro-autopulsatile infusion pump which was designed by the authors to treat a patient with hypothalamic amenorrhea and another one with polycystic ovary (PCO) LH-RH 15-20 μg at the frequency of every 90 minutes were given subcutaneously. After 31 successive days of treatment, the patient with hypothalamic amenorrhea demonstrated that (1) the BBT rose to 0.4-0.5°C on the 18th day after medication and mantained for 13 days, (2) cervical mucus showed its transparency and elasticity before ovulation, (3) Bsonography showed the main follicle enlarged to 22×17 mm on the 15th day and ruptured on the 18th day of LH-RH therapy and (4) serum FSH, LH, E_2 and progesterone determined by radioimmunoassay revealed the levels of a normal ovulatory menstrual cycle.The patient with PCO failed to ovulate after 49 days of treatment, therefore wedge resection was performed on both ovaries. The ovulatory menstruation was recovered two months after operation. The dosage, frequency, route of administration and indication of LH-RH treatment are discussed.