大鼠单侧颈动脉阻断所致的脑缺血性损害和764-3脑保护作用的实验研究

Experimental studies on cerebral ischemic damage following unilateral carotid occlusion and the protective effect of 764-3 in rats

采用三种方式暂时阻断大鼠单侧颈动脉(CA):阻断颈总动脉(CCA),阻断颈内动脉(ICA),阻断 CCA、ICA 和颈外动脉(ECA)。此三种阻断方式可造成脑缺血性损害,但不引起脑梗塞和神经缺失症状。以同时阻断 CCA、ICA 和 ECA 造成的脑缺血性损害最重,阻断 ICA 次之,阻断 CCA最轻。阻断单侧 CA1小时以上,可造成脑皮层神经细胞缺血性损害加重,若缺血时间延长可发生不可逆损害,伴有缺血性脑水肿。764-3作为脑保护剂,可降低由于阻断单侧 CA 引起的脑皮层前列腺素 F_(2α)(PGF_(2α)的增加,减轻神经细胞缺血性损害。

Temporary occlusion of unilateral carotidarteries in the rats was performed.The cere-bral ischemic damage manifested by mi-cropathological changes in neural cells. Nomacro-infarction and neural deficit symptomscould be found.Occlusion of common carotidartery (CCA) internal carotd artery (ICA),and external carotid artery (ECA) in the sametime cerebral ischemic damage were very se-vere.Damage often occlusion of the ICA,showed rather mild and the occlusion of theCCA was very mild.Occlusion of unilateral carotid arteries for more than one hour mayresult irreversible ischemic damage in neuralcells and cerebral edema.764-3 may reducethe level of prostaglandin F_(2α) (PGF_(2α) in cere-bral cortex and the severity of ischemic dam-age of neural cells.