Multiload Cu-375宫内节育器对月经血量、血红蛋白,平均红细胞血红蛋白、血清铁蛋白的影响

INFLUENCE OF MULTILOAD Cu-375 IUD UPON MENSTRUAL BLOOD LOSS, HEMOGLOBIN LEVEL, MEAN CORPUSCULAR HEMOGLOBIN CONCENTRATION AND SERUM FERRITIN

本文报告了21例健康妇女放置Multiload Cu-375宫内节育器(ML Cu-375 IUD)前后月经血量、血清铁蛋白浓度和血液学指标的变化,并观察了使用一年的情况。月经血量于放置后较放置前有明显增加,至放置后12周期仍未恢复到放置前水平。血清铁蛋白浓度于放置后3、6和12周期(分别为31.4、41.2和44.6ng/ml)均较放置前(56.3ng/ml)降低,除放置后第3周期与放置前比较差异有显著性(P<0.05)外,余两者无统计学意义。放置IUD后血红蛋白浓度<12g/dl和平均红细胞血红蛋白浓度<30％者,以及血清铁蛋白浓度<14ng/ml者的百分率显著增加。提示放置IUD后贫血的发生率将显著增加。

In 21 women, the menstrual blood loss (MBL) was estimated and concentrations of serum ferritin and other hematological indices were determined in the cycle before, and the 3rd, 6th and 12th cycles after insertion of ML Cu-475 IUD. The results indicated that the MBL before IUD insertion was much lower than those after insertion and the mean MBL in the 12th cycle did not recover to the baseline level. The mean serum ferritin before IUD insertion was 56.3ng/ml and significantly fell to a low level in the 3rd cycle. In the 6th and 12th cycles, the levels were still lower, but not significant statistically. Also, the percentages of the women with mean Hb<12g/dl, mean corpuscular hemoglobin concentration<30% and mean serum ferritin<14ng/ml were significantly increased after IUD using. These suggested that the incidence of anemia was apparently increased in women using ML Cu-375 IUD.