绝经后骨质疏松与雌激素的关系

RELATIONSHIP BETWEEN OSTEOPOROSIS AND ESTROGEN IN POSTMENOPAUSAL WOMEN

检测110例绝经后妇女及40例绝经前妇女的空腹尿钙与尿肌酐的比值及雌二醇的水平,并分析两者的关系。检测结果表明绝经后空腹尿钙与尿肌酐的比值明显高于绝经前相应的比值。绝经前妇女的雌激素值明显高于绝经后妇女的雌激素值,两者数据呈显著的负相关。空腹尿钙与尿肌酐比值高说明骨吸收速度加快,容易发生骨质疏松。雌激素水平低影响骨的合成,是造成骨质疏松的直接原因。绝经后妇女E_2水平低,尿Ca:Cr比值高,有发生骨质疏松的趋势,对23例有骨质疏松趋势的患者进行雌激素替代疗法,得到了一定的疗效。

Fasting urinary calcium to creatinine ratio and estradiol were defermined in 110 postmenopausal and 40 premenopausal women. The relationship between the ratio and estrogen in 2 groups was analyzed. The results showed that the ratio of urinary calcium to creatinine in postmenopausal women was obviously higher than that in premenopausal women, 0.203±0.138 and 0.120±0.052 respectively (P<0.01), whereas the value of estradiol in premenopausal women was higher than that in postmenopausal women, 67.50±59 pg/ml and 17.67±14 pg/ml (P<0.01) respectively. Significant negative correlation of the ratio and estrogen was noted. Fasting urinary calcium to creatinine ratio indicates accelerated bone resorption. Postmenopausal women with low estrogen level and high calcium to creatinine ratio are prone to have osteoporosis and risk of fracture.Satisfactory results were obtained in 23 postmenopausal women with osteoporosis tendency ofler estrogen therapy.