大肠上皮性良恶性肿瘤细胞AgNOR定量研究

A QUANTITATIVE STUDY ON THE AgNOR OF EPITHELIAL TUMOR CELLS OF COLON

采用胶体银染法对人大肠上皮各种良、恶性肿瘤细胞核仁组织区的相关嗜银蛋白(Ag-NOR)进行了定量研究,结果显示:良、恶性肿瘤之间AgNOR的数量、大小、形态及分布的差异均有显著性(P<0.01)。综合分析AgNOR的各项定量指标可作为区别良、恶性肿瘤的辅助参考依据,尤其以AgNOR颗粒的大小及形态更有参考价值。

The nuclear organizer regions(NOR)of benign and malignant large bowel lesions have been identified by means of an argyrophilic technique (AgNOR). This method reveals AgNOR as black dots in the nuclei of cells. It was found that the number,size,shape and location of AgNOR all have a statistical difference between benign and malignant lesions. Thus,they could be considered to be the markers for differential diagnosis of benign and malignant lesions,especially the size and shape of AgNOR. The characteristics of AgNOR of both villous adenomas and highly differentiated adenocarcinomas are similar which suggestes the former has a tendency fowards malignancy.