白血病细胞产生的免疫抑制因子对IL_2作用的影响

EFFECT OF IL2 ACTION BY IMMUNOSUPPRESSIVE FACTOR PRODUCED BY LEUKEMIA CELL

人白血病细胞产生的免疫抑制因子（ＴＤＳＦ）作用于人外周血单个核细胞（ＰＢＭＣ）６小时，即可抑制白细胞介素２（ＩＬ２）产生，与对照组相比Ｐ＜０．０ｌ。当ＴＤＳＦ存在时，经驯化的ＰＢＭＣ效应细胞对外源性ＩＬ２反应显著减弱，表明ＴＤＳＦ能抑制ＩＬ２的作用。ＰＨＡ－Ｐ刺激ＰＢＭＣ增殖，但ＴＤＳＦ使其增殖抑制。表明：ＴＤＳＦ能抑制ＩＬ２产生及其作用；抗癌药对ＴＤＳＦ的分泌有部分阻抑作用。

Leukenia cell lines produces a tumor-derived immunosuppressive factor(TDSF)、which inhibited the proluction of IL2 after action on PBMC for 6 h The responseof PBMC treated with PHA-p to exogeneous IL2 was significantly decreased in the presenceof TDSF,suggesting that TDSF can inhibit the acion of IL2.The effect of PBMC afterbeing stimulated with PHA-P was significantly suppressed by TDSF in dose-dependent manner。These findings suggest that the inhibitory a dion of TDSF on T cell activation and proliferationassociated with IL2.The synthesis and secretion of TDSF in acute non-lymphocytic leuke miawere partially inhibited by anticancer drugs.