钆喷酸二葡甲胺的致突性研究

MUTAGENIC STUDIES 0F GADOPENLETIC ACIDDIMEGLUMINE SALT

本文应用鼠伤寒沙门菌／徽粒体试验，小鼠骨髓细胞微核试验和体外哺乳动物细胞（ＣＨＬ）染色体畸变试验对钆喷酸二葡甲胺进行了致突性研究．结果表明：钆喷酸二葡甲胺各剂量ＴＡ９７，ＴＡ９８，ＴＡ１００，ＴＡ１０２在加和不加Ｓ９条件下均无致突性。在徽核试验中，各剂量诱发小鼠骨髓多染红细胞的微核率与阴性对照相比，无显著差异（Ｐ＞０．０５）染色体畸变试验也未观察到钆喷酸二葡甲胺对体外培养细胞的损伤作用．研究表明，钆喷酸二葡甲胺对原核生物和哺乳动物细胞无致突变作用．

Mutagenicty of Gadopenletic acid dimeglumine salt was studied using thesalmonella/microsome assay,murine micronucleus assay and chromosome aberration as-say,The mutagenic activity of Gadopenletic acid dimeglumine salt was not observed inTA97,TA98,TA100 and TA102 with and without S9 activation under the doses used,NoSignificant differences in the number of micronuleated PCE were found in any of the testinggroups compared with negative control in mice,P>005).In chromosome aberration test,the effect of chromosomal damage of Gaeopenletic acid dimeglumine salt was not found ei-ther in CHL cells.