大刺猴头（88）多糖抗突变、抗氧化及对免疫功能影响的研究

STUDY ON ANTIMUTATION AND ANTIOXIDATION OF THE GERICIUM POLYSACCHARIDE (HEPS)AND THE EFFECTSON IMMUKNITY

本实验观察了大刺猴头多糖（Ｈｅｒｉｃｌｉｕｍｐｏｌｙｓａｃｃｈａｒｉｄｅ（ＨＥＰＳ）对大肠杆菌ＳＯＳ应答的抑制作用；径口给大鼠ＨＥＰＳ（３０ｄ）测定大鼠血液和肝组织中超氧化物歧化酶（ｓｕｐｅｒｏｘｘｉｄｅｄｉｓｕｍｕｔａｓｅＳＯＤ），脂质过氧化物丙三醛（Ｍａｌｏｎｙｌｄｉａｌｄｅｇｙｄｅ（ＭＤＡ）含量的变化；经口给小鼠（ＨＥＰＳ）（３０ｄ），其对小鼠腹腔吞噬率、吞噬指数，脏器指数的影响。结果表明：ＨＥＰＳ可以抑制由（ＭｉｔｏｍｙｃｉｎｃＭＭＣ）诱导的ＳＯＳ应答，其抑制率大肠杆菌ＰＱ３５为６４％，ＰＱ３７为５６％；经口给大鼠ＨＥＰＳ其血液及肝匀浆中ＳＯＤ含量均高于对照组。ＭＤＡ的含量均低于对照组，各自２组比较分别有非常显著性差异及显著性差异（Ｐ＜０．０１，ｐ＜０．０５）。ＨＥＰＳ组小鼠的腹腔吞噬细胞吞噬率、吞噬指数，胸腺指数，腺指数与对照组比较也有非常显著性差异（ｐ＜０．０１）。结果提示：大刺猴头（８８）（ＨＥＰＳ）在本实验体系表现有抗突变，抗氧化及增强免疫功能的作用。

The inhibitory effects of the Hericium polysaccharede (HEPS) to E. coli bacillulsSOS response were observed in this study. After rats and mice were given HEPS(for thirtydays), superoxide dismuktase (SOD) in blood and in liver as well as the content changes ofMalonyldialdehyde(MDA) of rates were dctemined while the effects to thc phagocyticrate, phagocytic index, organ of body index of intrapcritoneal phagocyte of mice were ob-served. Results show that HEPS can inhibit SOS response induccd by MMC. The inhibi-tion rates of colibacillus PQ35,PQ37 are 64% and 56% respeetively; HEPS was given tomice by mouth, and the content of SOD in crythrocyte and in liver homogenate of rats in HEPS group was higher than that of the control,while tlhe content of MDA was de-creascd. The two groups have remarkable differences respectively(P<0.01,P<0.05). Thephagocytic rates, phagocytic indexes, organ of body indexes of intraperitoneal phagocyte ofmice between the HEPS group and control also have remarkable differences (P<0.01). Re-sults show that HEPS possess the function of antimutation, antioxidation and immunityfrom these test systems.