氯乙烯中毒性肝病和乙型肝炎染色体畸变分析

AN ANALYSIS OF CHROMOSOMAL ABERRATIONS IN THEPATIENTS OF LIVER DISEASE INDUCED BY VINYLCHLORIDE AND HEPATITIS B PATIENTS

本文对２１例氯乙烯中毒性肝病、９例乙型肝炎患者及１０例正常人外周血淋巴细胞染色体Ｇ显带分析表明：中毒性肝病组、乙肝组染色体数目畸变率和结构畸变率均明显高于对照组（Ｐ＜０．０１）．其中氯乙烯中毒性肝病组染色体结构畸变率还高于乙肝组（Ｐ＜０．０１）。对结构畸变中断裂点的分析表明，两种肝病的断裂点分布不同，同时还发现染色体上某些位点断裂频率较高，并初步探讨了这些位点和肿瘤发生之间的关系。

In the present study ,we used chromosomal G─banding method to examine 21Iiver disease patients who had been exposed to vinyl chloride for above 10 years,9hepatitis B patients and 10 norrnal controls. The results showed that the frequencies ofchromosomal numerical aberrations, structural aberrations of vinyl chloride liver diseasegroup and hepatitis B group were significantly higher than those observed in the controlgroup.The relationship between the breaking sites of chromosomal rearrangement,activation of oncogenes and incidence of cancer was also discussed.