升血因子对小鼠骨髓多染性红细胞微核的影响

THE EFFECT OF PLACENTAL EXTRACTS ON MICRONUCLE-US OF BONE MARROW POLYCIIROMATICA ERYTHROCYTESIN MICE

作者在环磷酰按所致小鼠骨髓多染性红细胞微核细胞率增高的模型上，研究了升血因子的防治效应。结果发现，升血因子可明显降低环磷酰胺对小鼠骨髓多染性红细胞微核细胞率的增高，连续４ｄ经腹腔分别注射６２．６０，２５．０４，１２．５２，６．２６和０．２５ｕ／ｋｇ剂量的升血因子，且第４ｄ同时注射５０ｍｇ／ｋｇ剂量的环磷酰胺，小鼠骨髓多染性红细胞微核细胞率分别为９．５０±１．３４．１２．１７±１．０３１３．５０±１．９２，１６．５８士１．９３和１９．６７±１．８９％，与阳性环磷酰胺对照组（２４．７５±１．４４‰）相比有显著性差异（Ｐ＜０．００１，０．００１．０．００１，０．００１和０．００１．ｎ＝６）。结果表明，升血因子对环磷酰胺所致小鼠骨髓多染性红细胞微核细胞率的增加有明显的防治作用，对骨髓多染性红细胞的遗传物质也有显著的保护作用。

The protective effect of placental extracts(PE)on increase of bone marrowpolychromatic erythrocytes micronucleus(PECMN)rates in male Kunming strain mice in-duced by cyclophosphamidum(CP)were studied. It is found that PE remarkedly de-creased the Cp一 induced increase of bone marrow PECMN rate. Conseculive injection ofPE at doses of CP 50mg/kg in the same way at 4th day , 24hours later , the rates ofPECMN in bone marow were remarkedly dropped to the values 9. 50士1. 34, 12. 17 ± l.03, 13. 50士1. 92, 16.58± 1. 93, and l9. 67± 1. 89 respectively compare with the value(24. 75±1. 44‰)of postive control(P<0. 001.0. 001,0. 001,0. 00l and 0. 0l in order,n=6). The above result showed that PE can inhibit the Cp一induced increase of the rateof PECMN in mouse bone marrow , Futhermore, this indicate that PE can protect heredi-tary materials in bonemarrow PEC of mice.