环氧乙烷的遗传毒性

STUDY ON THE GENOTOXICITY OF ETHYLENE OXIDEⅡ. SPERM ABNORMALITIES TEST IN MICE

环氧乙烷的遗传毒性张龄综述余应年审校上海职工医学院上海２００２３７浙江医科大学１．前言环氧乙烷（ｅｔｈｙｌｅｎｅｏｘｉｄｅ．Ｅｔｏ）在常温常压下为无色易燃气体，４℃时冷凝为液体，沸点为１０．４℃，在室温下通常是无色，但当其浓度高于７００ｐｐｍ（１ｐｐ...

The mutation frequencies of sperm abnormalities in mice with subacute and subchronic testswere studied.We found the only significant mutation frequency (152± 76.27) between the high concentra-tion (540mg/m)group and control group of subacute test on the seventh day(P< 0.01 ). And thedose ─effect relationship is dominant. There are no significant difference between the other concentrdationgroups and control groups after seven days.But in the subchronic test with the mice inhaling ethylene ox-ide for 14 weeks continuously,low(54mg/m3)and high(360mg/m3)concentration groups were compared with control group and their mutation frequencies are obvious(They are 29.4±16.24,P<0.05 and52.91±11.97,P<0.001,respectively). These results showed that it is evident mutagenesis toinhaleethylene oxide for a long time although in the low concentration.It coincides with the actual situation ofworkers.who are occupationally exposured to chemicals for a long time. We must pay attention to the possibility of teratogenesis in offspring and infertility among male workers potentally exposed to ethyleneoxide.and this subject should be studied further.