肝癌患者血清甲状腺激素测定及其临床意义

CHANGES OF SERUM THYR0ID HORM0NE IN PRIMARY LIVER CANCER AND ITS CLINICAL SIGNIFICANCE

应用放射免疫分析法检测９６例肝癌、３１例失代偿期肝硬化患者和３２例正常人血清甲状腺激素。结果表明肝癌患者随着病程愈晚，Ｔ３、ＦＴ３下降和γＴ３上升愈明显，Ⅲ期肝癌组低Ｔ３血症发生率为７７．７８％，高于Ⅱ期肝癌组（Ｐ＜０．０１）。肝癌患者血清Ｔ４、ＦＴ４值高于失代偿期肝硬化（Ｐ＜０．０１）。Ⅱ期、Ⅲ期两组肝癌患者高Ｔ４血症发生率分别为３９．２２％和３７．７８％，其血清ＴＳＨ浓度大多正常或轻度增高。本文对肝癌患者血清甲状腺激素变化的特点及其临床意义进行了讨论。

Blood concentration of thyroid hormome was measured by radioimmunoas-say in 96 patients with primary liver cancer( PLC)and 3l patients with decompensated livercirrhosis and 32 normal subjects.The results showed that along with PLC course developm-ent ,T3, FT3 decrease and γT3 increase became more and more obvious.The occurrence rateof low T3 syndrome of stage Ⅲ PLC was higher than that of stage Ⅱ PLC(p<0.01 ). Mean-while serum thyroxine and free thyroxine levels in patients with PLC were significantly higherthan those with decompensated liver cirrhosis (p< 0.0l).Among the PLC patients under ourobservation ,hyperthy roxinaemia covered 38.54%(37/96).The resuls also showed that serumthyroid stimulating hormone(TSH)concentration in the majority of PLC patients was normalor was slightly increased The change characteristics of serum thyroid hormone in patientswith PLC and clincal significance are discussed.