摘要
以ADP为激聚剂,检测了273例鼻咽癌和132名正常人的血小板最大聚集率(MAR)。结果显示:鼻咽癌组的MAR比对照组增高有非常显著意义(P<0.001),其疗前,疗中、疗后复发和有远处转移者的MAR均比对照组高(P<0.001),但放疗后病情稳定者的MAR无明显变化。按临床分期,MAR有随病情发展而逐渐增高的倾向,其中Ⅰ期与Ⅲ、Ⅳ期之间的差异有显著和非常显著意义(P<0.05,P<0.01),提示鼻咽癌与血小板聚集有密切关系,讨论恶性肿瘤与血小板聚集的机制。
The ADP induced maximum platelet aggregation(MAR)in 273 patients with masopharyngeal carinoma(NPC) ang 132 healthy adult are estimated.The MAR of NPC was significantly higher(p< 0.001)than that of the control group.All MAR meas-ured during pre-treatinent,inter-treatment,recurrence of post-treatment and that withdistant metastasis was higher than that of control group,but the MAR of non-recurr-ence in post-treatinent did not show any differences significatly. A ccording to clinic st-age,the MAR enhanced gradually with disease develeping in NPC,among of them,thedifference between the MAR in stage Ⅰ and stage Ⅲ,Ⅳ was significant(p<0.05 and p<0.01)It is suggested that the relationship might exist closely between NPC and platelet agg-regntion. The mechanism responsible for the enhanced platelet aggregation in malignanttumor is discussed.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1994年第1期60-63,共4页
Chinese Journal of Cancer
关键词
癌
血小板聚集
鼻咽肿瘤
Nasopharyng eal carc inom a
Platelet aggregatfon