丝裂霉素、长春花硷和顺铂联合治疗晚期非小细胞肺癌

COMBIN ATION OF MITOMYCIN,VINBLASTINE,AND CISPLATIN (MVP)IN THE TREATMENTOF ADVANCED NON-SMALL CELL LUNG CANCER

６８例Ⅲ～Ⅳ期非小细胞肺癌患者用丝裂霉素（８－１０ｍｇ／Ｍ２，第一天），长春花硷（１０ｍｇ，第６天），顺铂（２０ｍｇ／Ｍ２，第１至５天）联合化疗，每４周重复疗程。其中Ⅲａ期１０例，Ⅲｂ期３５例，Ⅳ期２３例。腺癌４７例，鳞癌１８例，鳞腺癌３例。完全缓解３例（４．４％），部分缓解３３例（４８．５％），总有效率５２．９％。主要毒副作用为胃肠道反应──恶心、呕吐和骨髓抑制──白细胞和血红蛋白下降。

Sixty-eight patients with advanced non-Small cell lung cancer (NSCLC) were treated with combination chemotherapy of mitomycin(8-10mg/m2,dl),vinblastine(10mg, d6), and ciSplatin(20mg/m2,d1-5) (MVP),and repeated every 4 weeks. Among them, 10 patient had stage Ⅲa diease, 35 patients had stageⅢb di-sease, 23 patients had stage Ⅳ disease. There were 47 adenocarcinomas, 18 squam-ous cell carcinomas, and 3 squamous-adencarcinomas. Three patients showed complete response(4.4%), 33 patients showed partial response (48.5%),the overall response rate was 52.9%。 The major toxic effec ts was gastrointestinaltract reaction-nausea,vo-miting and myelosuppession-leukopenia and anemia. However,thrombocytopenia was infrequent.