恶性肿瘤患者血清层粘蛋白含量的初步研究

DETERMINATION OF SERUM LAMININ IN PATIENTS WITH ADVANCED CANCER

利用酶联免疫吸附法（ＥＬＩＳＡ）检测了１３５例恶性肿瘤患者血清中层粘蛋白（Ｌａｍｉｎｉｎ，ＬＮ）的含量，比较了良恶性肿瘤及健康成人血清ＬＮ的差别，对ＬＮ在癌变中的机制进行了初步探讨。结果表明，所有恶性肿瘤患者血清ＬＮ值均高于健康对照（Ｐ＜０．００１），并且高于良性肿瘤患者（Ｐ＜０．００１），良性肿瘤和健康组之间没有差别（Ｐ＞０．０５）。以正常人ＬＮ值上限为界，恶性肿瘤阳性分布率为７４．８％，良性肿瘤１３％，正常人假阳性为８．５％。提示ＬＮ可作为辅助诊断恶性肿瘤、区分肿瘤良恶性的一项重要参考指标。

Serum laminin in patients with advanced cancer was detected b。ELISA method.The level of laminin was significantly increased in advanced cancer patients in comparison with healthy controls and with benign tumor patients(p< 0.001). Therere was no diffrence between benign tumor patients and healthy controls(p>0.05)。About two thirds of the patients with advanced cancer showed values for serum laminin that exceeded the upper limit of normal range(74.8%).value of benign tumor patie-nts was only 13 % exceeded this level. The results suggested that concentrations of lami-nin in serum may be helpful to the diagnosis of cancer or to the differentcaldiagnosis of patients with carcinoma with benign disease.