格拉诺赛特（基因重组粒细胞集落刺激因子）临床验证报告

EVALUATION OF GRANOCYTE IN CANCER CHEMOTHERAPY

４４例经病理检查确实的恶性肿瘤，包括肺癌、恶性淋巴瘤、乳癌、滋养叶细胞癌分别应用四种不同的联合化疗，并在第一和第二疗程中分别加用或不用格拉诺赛特，比较二个疗程中患者中性粒细胞绝对数（ＡＮＣ）的动态变化。结果证实，格拉诺赛特可提高患者ＡＮＣ的平均水平，缩短粒细胞缺乏的持续时间和促进ＡＮＣ的恢复，而不良作用较低，因此成为肿瘤化疗中有价值的辅助药物。

cases of malignancies including lung cancer malignant lymphoma,breast cancer and trophoblatic cancer were treated with combination chemotherapy. Eachpatient received one treatment cycle (with granocyte) and one control cycle(without gra-nocyte).The change of absolute neutrophil count during chemotherapy course betweentreatment cycles and control cycles were compared. The results showedthat in granocytetreated cycles neutropenia could be prevented or attenuated,with the neutrophil nadirhigher and neutrphil recovery earlier as compared to the control cycles. The study confir-med the value of granocyte as a valuable ajuvant in caocer chemotherapy.