N－（膦羧甲基）α－甘氨酸的合成与应用

The Synthesis and Use of N-(phosphonomethyl)α glycine

叙述了Ｎ－（膦羧甲基）α－甘氨酸的化学合成及其在除草剂方面的应用。该化合物有五条合成路线：曼尼斯反应、加成反应、取代反应、氧化还原反应和其他反应。其中曼尼斯反应较简便，可由甘氨酸、甲醛和亚磷酸酯一步合成标题化合物。Ｎ－（膦羧甲基）α－甘氨酸是一种高效广谱内吸传导型叶片喷药除草剂，它能有效地控制世界上危害最大的７８种恶性杂草中的７６种，还能“斩草除根”。除草机理为竞争性抑制５－烯醇丙酮莽草酸－３－磷酸合成酶（ＥＰＳＰａｓｅ）。

This article deals With the Chemical Synthesis of N-(Phosphonomethyl) a glycine and its application for the herbicides.The N(phosphonomethyl)αglycine has five Synthetic routes:Mannich's,addition,substitution,oxidation-reduction and et at.Mannich's react is simple niethods with which he made from the glycine,aldehyde and ester phosph put together in different forms to make compounds by one-step.N(phosphonomethyl)α glycine is a nonselectivetranslocated spray which can effectually control 76 of 78 ill weeds in the world over and that‘pluck up the evil by the roots’.The mechanism of herbicide action is competitive inhibitor smenolpyruvoylshikimate-3- phosphatasynthase(EPSPase).