抗溃疡性结肠炎新药IPSALAZIDE的合成

Synthesis of A New Kind of Anti-inflammatory Bowel Disease Agents

以对硝基苯甲酸为原料，经氯化后，被氨基乙酸取代，得到对硝基苯甲酰氨基乙酸，再经还原，重氮化后，与水杨酸偶合，合成了抗溃疡性结肠炎新药－５［［４－［（羧甲基）甲酰氨］苯］偶氮基］水杨酸（Ｉｐｓａｌａｚｉｄｅ）。并做了红外光谱鉴定。

Anti-inflaminatory Agents-5[[4-[(Carboxymethyl)Carbamoyl]penyl azo]Salicylic Acid(Ipsalazide) have been Synthesized from P-nitrobenzoic Acid and Testified By IR The Synthesis Consists of four steps.