血清肿瘤标志物在肺癌诊断中的价值

The Value of Serum Tumor Markers to the Diagnosis of Lung Cancer

采用放射免疫测定法测定４０例肺部疾病患者血清中ＤＮＡ聚合酶（ＤＮＡＰ）、血清总唾液酸（ＴＳＡ）、血清铁蛋白（ＳＦ）、甲胎蛋白（ＡＦＤ）及癌胚抗原（ＣＥＡ）水平。肺癌组和良性肺病组间的ＤＮＡ－Ｐ和ＡＦＰ无差异（Ｐ＞０．０５）；肺癌组的ＴＳＡ、ＳＦ、ＣＥＡ分别是６１４．９８±６８．０８ｍｇ·Ｌ－１、３６４．３９±１３７．２２μｇ·Ｌ－１、２１．０８±１３．３３μｇ·Ｌ－１，均明显高于良性肺病组，两组间Ｐ＜０．００１。单独检测血中ＴＳＡ、ＳＰ、ＣＥＡ，肺癌组的阳性率分别是６０％（１２／２０）、７０％（１４／２０）、６５％（１３／２０）；联合测定，以该３项指标中任２项阳性，可高度怀疑其肺癌的可能性，其敏感性为８０％（１６／２０），特异性可达９０％。

The levels of DNA-P, TSA, SF, AFP and CEA in the sera of 40 cases of the patients suffering from lung disorders were determined by RIA. The results showed: the difference of DNA-P and AFP between lung cancer group and benign diseases group showed statistically (P>0.05) no in significance; TSA, SF and CEA in lung cancer group, which were 614.98±68.08 mg·L-1, 364.39±137. 22 μg·L-1 and 21.08±13.33μg·L-i respectively, were all obviously greater than those in benign diseases group (P<0.001). When only assaying serum TSA or SF or CEA, the positive rate of lung cancer was 60% (12/20), 70%(14/20) and 65% (13/20) respectively. when assaying three indexes simultaneously, the possibility of bearing lung cancer may be suspected greatly when any two indexes out of three indexes above were positive, the sensitivity of lung cancer was 80% (16/20)and the specifacity was 90%.