130例黑色素瘤临床病理分析

Clinical and pathological analyses of 130 cases of melanoma

１３０例侵袭性黑色素瘤中，男性６９例，女性６１例；发病年龄１７～９３岁（中位年龄５５岁）。最常见部位为足底、鼻腔和肛管直肠。病理可分为１２个组织学亚型。免疫组化染色结果表明，２５例无色素性黑色素瘤Ｓ－１００染色全部阳性（阳性率１００％），ＨＭＢ４５染色２３例阳性（阳性率９２％），结果提示：Ｓ－１００和ＨＭＢ４５是诊断黑色素瘤一个较有价值的标志物。

This report presents the clinical aspects and pathological chenges of 130 cases of melanoma. Sixty-nine case male and sixty-one female with morbid age 17～93 years (median age 55 years). The most sites of involvement were the sole,the nasal cavity,and the anorectum. pathologically, histological types could be divided into twelve subtypes. The results of immunohistochemical study showed that 25 of 25 amelanotic melanoma were positive for S100 and 23 of 25 amelanotic melanoma for HMB45.These findings suggest that S-100 and HMB45 are very useful markers for diagnosing melanoma.