滋养细胞肿瘤AgNOR定量研究

QUANTITATIVE STUDY OF AgNOR IN TROPHOBLASTIC TUMORS

应用ＡｇＮＯＲ染色技术，对８０例滋养细胞肿瘤和１０例正常绒毛标本中细胞核内ＡｓＮＯＲ的数量、大小、形态进行观察和对比分析。结果表明，除葡萄胎与葡萄胎恶变组外，各组间细胞内ＡｇＮＯＲ均数有显著差异（（Ｐ＜０．０ｌ）．各组ＡｇＮＯＲ颗粒大小也有明显差异（ＰｓＴ＜０．０１ＣｓＴ＝０．６；ＰｃＴ＜０．０１ＣｃＴ＝０．４）．这些结果提示ＡｇＮＯＲ定量观察不仅有助于鉴别良、恶性肿瘤，而且有助于恶性肿瘤分型．但Ａｇ－ＮＯＲ技术对判断葡萄胎有无恶变无参考价值．

Nucleolar organizer region associated argyrophil proteins(AgNOR)technique wasused to investigate the changes of nuclear AgNOR with the resected trophoblastic tumor spec-mens of 80 cases and l0 normal placental tissues. It was found that there was significant differ-ence in the mean number of the AgNOR between the groups(P< 0. 0l ) execpt for that in thegroup of hydatidiform mole and malignant change of hydatidiform mole. This study also showedthat there was significant difference in the sizes of the AgNOR(PsT<0. 01 Csr=0. 6;PcT<0.0ICcT=0.4).It suggested that this method may help in differentiating benign tumors from malig-nant and typing malignant tumors, AgNOR technique showed no referential values in malignantchange of hydatidiform moles.