胃肠道癌产生异位HCG的研究

ECT0PIC PR0DUCTI0N 0F HUMAN CHORI0NICG0NAD0TROPIN BY GASTR0INTESTINAL ADEN0CARCINOMAS

本文对２５８例胃肠道癌进行了异位绒毛膜促性腺激素（ＨＣＧ）测定，其中３１例ＨＣＧ阳性，１７例β─ＨＣＧ阳性；而在ＨＣＧ阳性病例中，２４例为分化较差的腺癌，表明分化差的癌有产生ＨＣＧ的潜能，可能是与肿瘤细胞核内ＤＮＡ有关的ＨＣＧ片断解脱抑制或肿瘤细胞逆行性分化所致，故认为检测非滋养细胞肿瘤产生异位ＨＣＧ，对其患者的治疗和预后的判断可能有益.

Ectopic production of human chorionic goadotropin(HCG) in 258 cases of gastroin-testinal adenocarcionomas was measured by means of immunohistochemistry(PAP ).EctopicHCG was found in 31 of 258 cancer patients (12%),in which l7 were positive for β-HCG。Amongthe HCG positive cases, 24 were undifferentiated gastrointestinal adenocarcinomas.It shows thatundifferentiated carcinomas have the potential of HCG production。 The ectopic production ofHCG by nontrophoblastic tumors may be due to DNA derepression of genes for HCG or dediffer-entiation。 It suggests that measured ectopic production HCG in gastrointestinal adenocarcinomamight be useful in predicting the effectiveness of treatment and the prognosis of the disease。