大肠癌MC_5免疫组织化学定位研究

IMMUNOHISTOCHEMICAL LOCALIZED STUDY OF MC5 ANTIGEN IN LARGE INTESTINAL ADENOCARCINOMA

本文报道１６４例大肠癌ＭＣ＿５免疫组织化学的定位研究，分膜型、浆型及间质型.膜型ＭＣ＿５强阳性在高分化腺癌中占３８．４６％，分别与中、低分化腺癌相比，均有显著性差异Ｐ＞０．０５．间质型ＭＣ＿５阳性率在低分化腺癌中占８３．３３％，与高分化腺癌相比，Ｐ＜０．０１，但与中分化腺癌相比Ｐ＞０．０５，浆型ＭＣ＿５强阳性在各种分化类型中均较高.早期组８例均为高分化腺癌.膜型占７５％，与中、晚期组相比Ｐ＜０．０５，浆型和间质型的ＭＣ５阳性数在中、晚期组均较早期组多见.ＭＣ＿５抗原定位表达与大肠癌的组织类型有一定关系，并随抗原定位的演变与大肠癌变过程及分化程度有关.

Typically classified as apical,cytoplasmic and stromal types,this paper reports im-munohistochemical localized characteristics of MC5 antigen in l64 cases of large intestinal adeno-carcinooma, Among them,the apical type accounts for 38.46%of the well differentiated cancers,P<0.05 compared with that in moderate and less differentiated cancers,whereas the stromal typeaccounts for 83.33%,P<0. 0l compared with that in well and moderate differentiated cancers。There was no sign that cytoplasmic type was related with its histological classification, In the ear-ly stage group there were 8 cases of well differentiated large intestinal adenocarcinoma the apicaltype accounts for 75%,P<0.05 compared with that in the middle and late stage groups, Cyto-plasmic and stromal types were more common in middle and late stages。 The author believes thatthe expression type of MC5 antigen is not only related with the histological classification of thelarge intestinal adenocarcinoma but also with its differentiated level。