下丘脑后核内注射大豆皂甙可加强夹闭大鼠颈总动脉引起的升压反应

The pressor effect elicited by occldusion ofthe common carotid arteries promotedwith soyasaponin in PHN

本实验结果表明下丘脑后核（ＰＨＮ）是参与大豆皂甙（Ｔｓ）对中枢升压作用的主要核团之一。向ＰＨＮ内注入阿托品可减弱Ｔｓ在ＰＨＮ中的升压作用，这是通过激活Ｍ受体引起的。

Occlusion of the common carotid arteries(CAO ) in tirethane anaesthetized rats e-voked a potentiated respomse。 Injection of soyasaponin into PHN strengthened the capability of CAO reflex,and the pressor response induced by CAO was potentiated by soyasaponin, But the potentiation of pressor eftect induced by CAO after soyasaponin injection into PHN was weak- ened by atropine injection into PHN formerly.It indicated that cardiovascular reflex from carotid sinus might be involyed in the central pressor effect of soyasapoi1in。