黄芪皂甙对离体工作心脏的强心作用

Positive inotropic action of astragalus membranaceus atponins on lsolated Working Heart

本实验中，高浓度黄芪皂甙（５０、１００、２００μｇ／ｍＬ使Ｗｉｓｔａｒ大鼠离体工作心脏的心肌收缩性能立即呈剂量依赖性增强，作用与毒毛旋花子甙Ｋ（０．７２μｇ／ｎＬ）相似；低浓度黄芪皂甙（３０μｇ／ｍＬ），使心肌收缩性能立即减弱，提高细胞外钙不能反转此效应；洗脱后，黄芪皂甙的作用迅速消失。以上结果表明，黄茂皂戒对心肌有正性肌力作用，与强心甙类药物相似。

Astragalus membranaceius saponins(AMS)in high concentrations(50, 100, 200μg/mL)promptly increased the myocardial contractility on isolated working Wistar rat heart in adosage- dependent way, similarly to that of Strophanthini K( 0. 75 μg/mL ); while in lowconcentration(30 μg/mL,AMS decreased the myocardial contractility, and this effect could notbe conversed by raising [Ca2+] . After washing out AMS, all of its effects disappeared quickly。The above results suggested that AMS had a positive inotropic effect on myocardium, performingin a similar manner as cardiac glycosides。