脑室移植肾上腺髓质组织对冬眠黄鼠脑CA系统损毁的代偿

Compensatory Effects of ICV Grafted Adrenal Medullary Tissue for the Brain CA System Lesion in Ground Squirrels

前人的研究发现，动物入眠前，脑内ＮＥ活动下降，并在冬眠阵中保持低水平。本实验曾通过黄鼠侧脑室给予６－羟多巴胺（６－ＯＨＤＡ）损毁脑内儿茶酚胺（ＣＡ）神经元末梢，降低ＮＥ活动，发现可使动物入眠诱导期大大缩短，总的冬眠时间延长。在本实验中给黄鼠侧脑室注射６－ＯＨＤＡ后，又将自体一侧肾上腺髓质移植到侧脑室。结果表明，在ＣＡ降低的背景下，移植组织分泌的ＣＡ在冬眠行为上起到了一定的代偿作用：动物总冬眠无数，冬眠阵数及最长冬眠阵天数都减少。本实验进一步证明脑内ＮＥ系统参与冬眠阵的调控。

It was postulated that a cessation of brain adrenergic activity might pre-cede the onset of entry into hibernation.Measurements of brain NE content in cer-tain hibernators have indicated that the level of NE during the hibernating bout was lower than the euthermic state during winter. Our precursor work verified that de-pletion of NE activity by intraventricular injection of 6-OH DA might have a facili-tating effect on the entrance of hibernation,largely shorten the induction period and lengthen the total hibernation time.In this work the medullary tissue of animal′s own adrenal gland were grafted into the lateral ventricle of 6-OH DA treated ground squirrels.The results proved that on the background of lowered catecholamine level grafted medullary tissue had compensatory effects for the CA lesion in hibernating behaviors. The total hibernat-ing time,number of hibernation bouts and length of the maximal hibernating bout were significantly decreased than that of the control,at all,showing opposite effects to those of 6-OH DA treatment.As a result,it gives a strong support to the postu-lation that involvement of brain CA system in the processing of hibernation bout.