平喘酮立体化学的研究

STUDY ON THE STEREOCHEMISTRY OF 1,1'-BISISOMENTHONE

平喘酮又名１，１′－双异薄荷酮，它的２个几何异构体经立体化学研究证明：θｍｐ＝１６６～１６８℃的异构体是内消旋１，１′－双异薄荷酮，其构型为ＩＲ，１′Ｓ，４Ｓ，４′Ｒ。θｍｐ＝１３７～１３９℃的异构体是外消旋１，１′－双异薄荷酮，它的构型为（＋）旋光异构体是１Ｒ，１′Ｒ，４Ｓ，４′Ｓ，（－）旋光异构体是１Ｓ，１′Ｓ．４Ｒ，４′Ｒ。

A course of stereochemical study on the isomers of 1, 1'-bisisomenthone and the experimental results are reported. The two geometrical isomers of 1,1'-bisisomenthone are proved. One with θmp = 166～168℃ is meso-1,1'-bisisomenthone that configuration is 1R, 1'S, 4S, 4'R. Other with θmp =137～139℃ is (±) -1,1'-bisisomenthone that the configuration of enantiomer with dextrorotation is 1R, 1'R, 4S,4'R and with laevorotation is 1S, 1'S, 4R, 4'R.