摘要
用扫描电镜(SEM)研究了26例急性白血病细胞表面形态特征,同时结合光镜形态学(FAB)、免疫学和细胞遗传学分型(MIC),结果发现,SEM可更准确地区分急性淋巴细胞白血病(ALL)和急性非淋巴细胞白血病(ANLL)。在ANLL中,白血病粒细胞以表面横嵴为特征,白血病单核细胞以基底宽的膜性皱起为特征,SEM观察结果与MIC分型符合率为90.5%。在ALL病例中,SEM区分其免疫亚型有一定局限性。ANLL的疗效与SEM下白血病细胞的分化程度可能相关。
n order to
diagnose acute leukemia accurately on morphology,we studied 26
patient;with acute leukemia using scanning electron
microscope(SEM)and combined morphological,immunological and
cytogenetic(MIC)classification.The results indicated that
lymphoblastic and nonlymphoblastic leukemic cells can readily be
distinguished under the SEM.Among patients with acute nonlymphoid
leukemia(ANLL),myeloblasts and maturing myeloid cells had more raised
transverse ridgelike ruffled membrances.The concordance rate between
SEM observation and MIC classificatiOn was 90.6%.However,SEM does not
appear to contribute in difining the cell type in immunological
subtypes of ALL.It was relationship between therapy response and
differentiated degree of leukemic cells under the SEM in the patients
with ANLL.
出处
《北京医科大学学报》
CSCD
1994年第6期403-405,共3页
Journal of Peking University(Health Sciences)
关键词
扫描电镜
急性
白血病
诊断
Scanning electron microscopy
Acute leukemia