摘要
对５４例骨巨细胞瘤（ＧＣＴ）及２４例骨肉瘤（ＯＳ）进行了临床、病理及流式细胞ＤＮＡ定量分析的对比研究。１７例复发ＧＣＴ中，８例为超二倍体，平均ＤＩ值为１．０７±０．１３，平均Ｓ，Ｇ２／Ｍ期细胞占２０．７８±７．６４（％）。３７例原发ＧＣＴ中，仅５例为超二倍体，平均ＤＩ值为０．９７±０．１２，平均Ｓ，Ｇ２／Ｍ期细胞占１７．１４±６．６２（％）。原发与复发ＧＣＴ的ＤＮＡ含量，计学上有显著性差异（Ｐ＜０．０５）。ＯＳ中，１６例为超二倍体，８例为二倍体或亚二倍体，平均ＤＩ值为１．２２±０．２７，平均Ｓ，Ｇ２／Ｍ期细胞为２６、５９±１２．４（％）。结果表明，ＯＳ的ＤＮＡ含量明显高于ＧＣＴ的ＤＮＡ含量，前者的增殖期细胞比例也明显较后者高。
Correlative clinicopathological
and flow cytometric study was made on 54 GCTs and 24 osteosar-comas.
Among the 17 recurrent GCTs,eight had DI(DNA Index) value over 1.10
(Superdiploid);mean DI value was 1.07±0.13;and mean S,G2/M stage
cell acounfed for about 20.78%。 In 37 prim-。ary speclmens,only 5
had DI value over 1.10; mean DI value was 0. 97±0. 12;and mean
S.G2/M stage cell acounted for l7.14%, The difference of DNA content
between the primary and recurrenttumors was staisrically significant.
In 24 osteosarcomas, 16 case(66.7%)were superdipiploid, 6 diplo-id,
and 2 subdiploid.The mean DI value was 1.22±0.27; mean s、G2/M stage
cell was 26.59±12.4。It was shown that there were frank differences
between GCT and osteosarcoma in DNA analysis TheDNA content in
osreosarcoma is much higher than that in GCT and the percentage of S,
G2/M stagecell in osteosarcoma was also higher.The results indicated
that DNA content and cell cycle analysiscan reflect the degree of
malignancy of tumors.
出处
《北京医科大学学报》
CSCD
1994年第1期7-9,共3页
Journal of Peking University(Health Sciences)
