摘要
观察了神经降压素（ＮＴ）的肝细胞保护作用与Ｃａ２＋的关系。结果显示，醋氨酚使肝细胞Ｃａ２＋内流和肝脏钙含量增加，但对于线粒体Ｃａ２＋摄取及其钙含量无明显影响，表明细胞可能出现胞质Ｃａ２＋超载。若在醋氨酚之前给予ＮＴ则使肝细胞Ｃａ２＋内流明显减少，肝脏Ｃａ２＋含量有降低趋势，但线粒体钙含量显著增加。这些结果提示，ＮＴ通过减少Ｃａ２＋内流，增强线粒体贮存Ｃａ２＋的能力，部分缓解醋氨酚所致胞质Ｃａ２＋超载从而减轻细胞损伤。
n
the present Work the relation of hepatoprotection of
neurotensin(NT)to calcium was investi- gated.The results are as
follows: after administration of acetaminophen both the Ca2+ influx
in mouse hepatocytes and the total Ca2+ content in the liver
increased significantly,the Ca2+ content in mito- chondria and the
Ca2+ uptake by mitochondria showed no change,showing that there may
be cytosolic Ca2+ overload in hepatocytes. Pretreatment with NT
before acetaminophen completely revered the inc- rease of Ca2+
influx and reduced liver Ca2+ content slightly,but increased the
content of Ca2+ in mi- tochondria significantly.These results
indicate that NT may alleviate the overload of cytosolic Ca2+ by
decreasing Ca2+ influx and enhancing the ability for mitochondria to
trap Ca2+,and thus achieve hepatoprotective effect.
出处
《北京医科大学学报》
CSCD
1994年第2期87-89,共3页
Journal of Peking University(Health Sciences)
