摘要
对５０例有家族遗传史的高血压病人及５个家系进行系谱及ＨＬＡ关联等遗传学方面的研究；并以２１例非遗传高血压及１００例正常健康人对照。结果发现：（１）前组病人ＨＬＡ—Ｂ７５，ＤＱ７，Ｂｆｓｓ０７明显高于后者；（２）遗传高血压组ＨＬＡ—Ｂ７５在Ⅲ期高血压组增高，ＨＬＡ—ＣＷ，在Ⅱ期高血压组升高；而ＨＬＡ—Ｂ８的抗原频率在非遗传高血压组明显。提示原发性遗传高血压具有遗传基础，ＨＬＡ基因可能存在着原发性高血压的易感基因。
The paper presented a systemtic genetic spcium
and relativety of HLA of 50 cases(group A)and 5 families of
inheritable essential hypertension 21 cases(group B)of
non-inheritable essential hypertension and 100 casee (group C)of
normal persons.The result showed:(1)Group A patientsHLA-B75,DO7 BFSS
07 was higher than that in the group B and group .(2) HLA-B75
antigenfrequency was increased in 3 rd stage of inheritable essential
hypertension and HLA-Cw6 incrensed inthe 2 nd stage of the
disease,but HLA-B8 antigen frequencies increase in
non-inheritable,essentialhypertension,It suggested that inheritable
essential hypertension and a genetic base, and the inherita-ble mode
of the disease was in accords with multigenetic inheritable,and also
it might be an area ingenome of patients which was suscepstiable to
the inheritable essential hypertension.
出处
《北京医科大学学报》
CSCD
1994年第6期429-432,共4页
Journal of Peking University(Health Sciences)
基金
高教委博士基金
