甲状腺功能异常时血浆脂蛋白、载脂蛋白变化的研究

The study for the changes of plasma lipoprotein and apolipo protein in abnormal thyroid function

本文观察１３例甲亢与２７例甲减患者治疗前与中各项血脂代谢的变化，并与２０例正常人对照。观察结果表明，甲减时血胆固醇与甘油三脂明显升高；甲亢时明显下降。甲减时血ＨＤＬ－Ｃ无变化而ＬＤＬ－Ｃ明显升高；甲减时ＨＤＬ－Ｃ与ＬＤＬ－Ｃ均明显下降。甲减时ＡｐｏＡⅠ、ＡｐｏＢ与ＡｐｏｃⅡ均明显升高；甲亢时唯ＡｐｏＣⅡ明显下降。上述结果经治疗后均恢复至正常水平。本文认为ＬＤＬ－Ｃ升高是甲减高胆固醇血症的主要原因。

The change of serum lipid metabolism was observed in 13 cases of hyperthyroidism, 27 cases of hypothyroidism and 20 cases of control group before and during the treatment.The result showed that, the plasma cholesterol and triglyceride were significantly increased in hypothyroidism, and it was converse in hyperthyroidism.The serum HDL-C was no change and LDL-C was obviously increased in hypothyroidism,but both of HDL-C and LDL-C was significantly decreased in hyperthyroidism. The ApoAⅠ. ApoB and ApoCⅡ were significantly increased in hypothyroidism. The ApoAⅠ and ApoB in hyperthyroidism were no different with control group,but the ApoCⅡ was obviously decreased than in control group. All of above abnormal serum lipid were recovered to normal range after the treatment in both groups. This result indicates the LDL-C is an important reason causes hypercholesterolemia in hypothyroidism.