肥胖儿童血清脂蛋白谱剖析

Profiling of serum lipoprotein pattern in obese children

本实验检查了７０例单纯性肥胖儿童及６８例年龄、性别相当的正常对照组儿童的血糖、血脂、脂蛋白和载脂蛋白水平，结果表明，肥胖儿童的脂蛋白谱特点是低密度脂蛋白（以低密度脂蛋白胆固醇与载脂蛋白Ｂ表示）和脂蛋白（ａ）明显高于对照组；而高密度脂蛋白（以高密度脂蛋白胆固醇与载脂蛋白ＡＩ表示）则明显低于对照组，这种脂蛋白谱的改变，通常被认为有发生动脉粥样硬化的危险。

Serum levels of glucose, lipids, lipoproteins and apolipoproteins in 70 simple obese children and 68 age-and-sex-matched controls were analysed. The results showed that the low density lipoprotein (expressed by LDL-C and apoB)and lipoprotein(a)in the obese children was higher significantly than that in controls, and the high density lipoprotein'(expressed by HDL-C and apoAI)in the obese children was lower significantly than in controls. This characteristic lipoprotein pattern is regarded as the lipid risk factors of atherosclerotic cardiovascular diseases.