系统性红斑狼疮中枢神经系统病变的诊断及治疗

The diagnosis and treatment of 72 patients with central nervous system involvement of systemic lupus erythematosus

本文分析了７２例中枢神经系统（ＣＮＳ）受累的系统性红斑狼疮（ＳＬＥ）患者，占我院住院ＳＬＥ患者的１４％。９２％为ＳＬＥ的活动期，并多在ＳＬＥ发病后２年内出现。血清抗心磷脂（ＣＬ）抗体与其关系密切，脑脊液（ＣＳＦ）８１％异常，大剂量甲基强的松龙冲击治疗可降低死亡率。

patients with systemic lupus erythematosus (SLE) complicated with central nervous system(CNS) involvement were analysed.The incidence was 14%of the inpatients with SLE.92%of those were classified as active SLE,and occurred within the first 2 years of the disease duration.Serum anticardiolipin antibodies were significantly correlated with the CNS symptorns. Abnormalities of the cerebrospinal fluid were found in 81% of the cases. The mortality of CNS SLE can be decreased in pulse treatment With methylprednisonlone.