摘要
本文报道了大丁甙在大鼠体内、外的代谢研究。通过对大鼠胃液和肠内容物的培养,证明大丁甙在大鼠的消化道内发生了转化,并鉴定了主要代谢物的结构。发现4-羟基香豆精在体内的一种新代谢途径。对灌胃给药的大鼠尿及粪便的研究也证明了代谢物的存在。由于代谢产物在体外呈抑菌活性,从而证明大丁甙在动物体内经过代谢,转化成代谢产物而发挥抑菌活性。该研究为今后更好地应用大丁草提供了理论依据。
The studies reported here were about the metabolism of Gerberinside (V) in rats invitro and in vivo. The V was changed in alimentary canal of rats when cultured withgastrointestinal microorganisms. The main metabolites bad antibacterial activities and thestructures were identified. A new metabolic way was discovered.
关键词
大丁草
大丁甙
药代谢动力学
Gerbera anandria(L.) Sch Bip
Gerberinside
Metabolism
