摘要
本文报告了从河北采集的东亚钳蝎(Buthus Martensii Karsch)毒的镇痛作用。用小鼠扭体法、小鼠热辐射甩尾法、大鼠三叉神经诱发皮层电位法试验了蝎毒的镇痛作用,并与阿斯匹林、安痛定和吗啡进行了比较。实验结果表明蝎毒对内脏痛、皮肤灼痛和三叉神经诱发皮层电位有较强的抑制作用,蝎毒的量效关系曲线近似S型。
Reported in this paper is the analgesic effect of venom collected from scorpi-ons of Buthus Martensii karsch from Hebei Province. The analgesic effect of the venom was investigated in mice with writhing test,thermal radiation tail flicking test and test of cortical potential evoked by stimula-ting trifacial nerve. The analgesic effect of the venom was compared with thatof Aspirin, antonding and Morphine. The experimental results indicate that the venom has strong inhibitive effecton visceraglgia, skin thermalgia and cortical potential evoked by stimulating trifa-cial nerve. The dose-effect relationship curve of the venom is an S shaped one.
关键词
东亚钳蝎
镇痛作用
扭体法
蝎毒素
Venom
Buthus Martensii Karsch
Analgesic effect
Writhing test
Thermal radiation
Tail flicking test
Trifacial nerve
Cortical potential
