大黄防治实验性胃粘膜损伤机理分析

Analysis on the Mechanism of Protection and Therapy by Rhubarb on Gastric Mucosal Damage

本工作通过观察测定胃酸分泌,胃排空运动和胃壁粘液分泌的变化,初步探讨了中药大黄水浸煎剂对乙醇和消炎痛造成胃粘膜损伤的防治机理。结果表明:中药大黄可抑制胃排空速度,促进胃壁粘液分泌,并能预防乙醇和消炎痛造成的胃粘膜损伤,治疗乙醇造成的胃粘膜损伤。提示:中药大黄防治胃粘膜损伤机理与抑制胃酸分泌、抑制胃排空和促进胃壁粘液分泌有关。

The effect of rhubarb on gastric mucosal damage and mechanism of this protection were studied. The results show that: (1) Intra-gastric adminis-tration or duodenal infusion of rhubarb protected gastric mucosal damage induced by absolute ethanol. (2) Intragastric administration of rhubarb in dose of 0.125g/100g did not inhibited gastric acid secretion, but provented gastric mucosal damage. (3) Intragastric administration of rhubarb inhibited gastric emptying. (4) Intragastric or intraperitoneal administration of rhubarb increased gastric barrier mucus secretion and prevent gastric mucosal damage.our results suggest that protection and therapy of rhubarb on gastric mucosal damage might be due to stimulation of gastric mucus secretion and inhibition of gastric emptying.