去甲肾上腺素、甘氨酸、γ-氨基丁酸和L-谷氨酸对节段性与下行性脊髓场电位的影响

EFFECTS OF NORADRENALINE,GLYCINE, γ-AMINOBUTYRIC ACID AND L-GLUTAMIC ACID ON SPINAL FIELD POTENTIALS IN THE RAT

在麻醉的大鼠脊髓背部表面,记录刺激腓神经引起的节段性脊髓场电位(SP)与刺激C_2背索引起的下行性脊髓场电位(DP),观察在脊髓表面局部施加去甲肾上腺素(NE),甘氨酸(GLY),γ-氨基丁酸(GABA)和L-谷氨酸(L-GLU)时SP与DP的变化。结果表明,NE使SP与DP的N、P波波幅均明显降低,GLY、GABA、L-GLU明显降低SP与DP的N波波幅同时使SP与DP的P波明显增大。本文讨论了可能的作用机制。

Noradrenaline (NE), glucine (GLY),γ-aminobutyric acid (GABA) and Lglutamic acid (L-GLU) were locally applied to the dorsal surface of lumbar spinal cord on anesthetized and immobilized rats and their effects on segmental (SP) and descending (DP) spinal field potentials were examined. Both waves N and P of SP and DP were reduced markedly in amplitudes following local application of NE. A significant decrease in amplitude of wave N and a remarkable increase in wave P in both SP and DP were shown during the application of GLY, GABA and L-GLU. The results suggest that these neurotransmitters may be involved in the generation of waves N and P, particularly affecting the activities of interneurons in the spinal dorsal horn.