直链脂肪醇对豚鼠乳头肌慢动作电位的影响

EFFECTS OF ALIPHATIC ALCOHOLS ON SLOW ACTION POTENTIAL OF GUINEA—PIG PAPILLARY MUSCLE

本工作用相平面法观察和分析了乙醇、丁醇、己醇和辛醇对豚鼠乳头肌慢动作电位(APA,APD50,APD90,(?)_(max),(?)′_(max))及其所对应的钙电流(I_(max))和钾电流(I′_(max))的影响。结果表明:这四种脂肪醇对钙电流均有抑制作用,而对钾电流的影响,随碳原子数的加大从增强(乙醇)逐渐转化为削弱(已醇,辛醇)。并且碳链越长,产生这些效应所需脂肪醇的浓度越低,这提示醇的作用可能与它们的疏水性相关。

Effects of ethanol, butanol, hexanol and octanol on slow action potential (APA, APD50, _(max), and _(max)) and its correspondent I_(Ca) (I_(max)) and I_k (I'_(max)) of guinea-pig papillary muscle were measured and analysed, by using phase-plane method. The results showed that all of four alcohols inhibited calcium current of cardiac membranes, but the action on potassium current changed from enhancement (ethonol) to impairment (hexanol and octanol) with the increase in carbon number of alcohols. Furthermore, the longer the chains of alcohols, the less the concentration needed to produce these effects. This phenomenon suggests a possible correlation between the actions of aliphatic alcohols and their hydrophobic properties.