摘要
作者对１５例心脏直视手术患者心肌组织丙二醛（ＭＤＡ）含量及超氧化物岐化酶（ＳＯＤ）活性进行测定，并对心肌组织进行超微结构改变观察。结果表明，心肌组织ＭＤＡ含量在缺血再灌注后明显增加而ＳＯＤ活性明显下降。心脏复跳后心肌组织超微结构损害较心脏停跳后更明显。提示心肌组织氧自由基的产生主要是在再灌注期，是心肌组织缺血再灌注损伤的重要原因。
In order to
further study myocardical oxygen free radical and ultrastructural changesand its clinical
significance,determination of malondialdehyde(MDA)content and superoxide
dismutase(SOD)activity and ultrastructural observation were carried out in 15 children
undergoing open heartoperation. The results showed that myocardial MDA content was
obviously increased,SOD activity wassignifcantly decreased and myocardial ultrastracture was
severely damaged in reperfusion period ascompared with those in ischemia period.The results
suggest that myocardical oxygen free radicals areproduced primarily in the reperfusion period,
which are responsible for the ischemia-reperfusion injury ofcardiac mycyte.
出处
《承德医学院学报》
1994年第1期6-8,共3页
Journal of Chengde Medical University
关键词
心脏直视手术
氧
自由基
超微结构
open
heart operation
ischemia-reperfusion injry
oxygen free radical
