摘要
制备佐剂性关节炎大鼠模型后，观察了氯苯扎利钠（ＣＣＡ）对此动物模型下刀豆素Ａ（ＣｏｍＡ）诱导的Ｔ淋巴细胞增殖反应、脂多糖（ＬＰＳ）诱导Ｂ淋巴细胞增殖反应及腹腔巨噬细胞白细胞介素－１（ＩＬ－１）的活性等指标的动态影响。表明：ＣＣＡ对佐剂性关节炎大鼠降低的Ｔ淋巴细胞、Ｂ淋巴细胞的增殖反应有恢复正常的趋势，对升高的ＩＬ－１水平有降低作用，注射佐剂后第１４ｄ时药物对ＩＬ－１水平影响大，第２１ｄ时以对Ｔ、Ｂ淋巴细胞增殖反应的影响更为明显。
The effect
of lobenzarit disodium(CCA)on ConA-induced T lymphocytes proliferation ,on LPS-induced B
lymphocytes proliferation and on production of interleukin-1(IL-1)by peritoneal
macrophages(PM )in adjuvant arthritis (AA) rats were studied. The main results indicated that
ConA-induced T lymphocytes response and LPS-induced B lymphocytes response that had
been inhibited in AA rats were enhanced by in vivo treatment with CCA;Lps-induced IL-1
production by PM was decreased by CCA(in vivo).The effect of CCA was more obvious on IL-1
production in the 14th day after injecting Freund’s completed adjuvant (FCA) ,While the effect
were more important on T,B lymphocytes proliferation in the 21th day after injecting FCA.
出处
《承德医学院学报》
1994年第4期267-270,共4页
Journal of Chengde Medical University
关键词
氯苯扎利钠
佐剂性关节炎
免疫指标
adjuvant arthritis
lymphocyte proliferation
ConA :LPS
IL-1 activity Beijing Medical
University
