摘要
本文对ＨＢＶ感染后各型肝病２３８例患者血清中Ｐｒｅ－Ｓ２与ｐＨＳＡ－ｒ、ＨＢｅＡｇ标志相互关系及其临床意义进行比较。结果表明，Ｐｒｅ－Ｓ２在急性肝炎、慢活肝，ＨＢｓＡｇ无症状携带者中阳性检出率为最高，ｐＨＳＡ－ｒ、ＨＢｅＡｇ次之。亦观察到在Ｐｒｅ－Ｓ２阳性组中，ｐＨＳＡ－ｒ与ＨＢｅＡｇ阳性率相对增高（Ｐ＜０．０５，Ｐ＜０．００１），有显著差异，表明三者密切相关。Ｐｒｅ－Ｓ２更明确代表ＨＢＶ复制的感染性、传染性及对预后的估计、判断抗病毒之疗效。方法敏感、特异，适合临床广泛应用。
The serumal labels of Pre-S2, pHSA-r and HBeAg were comparativly studied in 238 patients with different type of HBV hepatosis. The results showed that the patients with acute or chromic active-hepatosis and with positive HBeAg had a significantly higher positive detected rate of Pre-S2than of pHSA-r and HBeAg, and for the patients with Pre-S2 positive detection they had a higher positive detection of pHSA-r and HBeAg(P<0.05). It suggested that Pre-S2 is a more accurate mark than other for representing infection of HBV, for estimating prognosis of the disease,and for judging the effect of antivirus therapy.
