大黄对实验性急性化脓性胆管炎早期血浆内毒素含量的影响

The effects of rhubarb on endotoxinbmia during acute suppurative cholangitis(ac) in rats

取ＳＤ大鼠，随机分为三组：正常组、盐水组、大黄组。利用大肠杆菌诱发急性化脓性胆管炎，盐水组和大黄组分别经口灌服生理盐水和大黄１ｍｌ／１００ｇ·日。以血浆内毒素及血清酶学为指标，观察了大黄对大鼠急性化脓性胆管炎早期血浆内毒素及肝功的影响。结果显示：１．盐水组术后３天内死亡４只，大黄组死亡２只，正常组无死亡。２．盐水组大鼠术后３天血浆内毒素含量明显升高，大黄组含量较盐水组明显降低（Ｐ＜０．０１）。３．术后３天血清ＡＫＰ和ＧＰＴ与正常组比均有明显增高，而盐水和大黄组之间无显著性差异（Ｐ＞０．０５）。结果表明大黄具有降低化脓性胆管炎大鼠的早期死亡率及显著降低内毒素血症的作用。

The acute suppurative cholangitis(AC) was induced on 20 SD rats with E. Coli through biliary fract retrograde injection.These animals were divided randomly into 2 groups and treated with Rhubarb(AC+R) and saline(AC+NS) 1ml/100 gm-day p.o. respectively, and were compared with other 10 normal rats as control. The contents of endotoxin and GPT,AKP in serum were observed during the early stage of AC. It was demonstrated that: 1.4 rats of AC+NS and 2 in AC+R group died at the 3rd day after operation,while the animals of normal group were all survival. 2.The serum endotoxin level of AC+NS increased significantly than that of AC+R(P<0.01).3.The serum AKP and GPT in rats of AC+NS and AC+R both increased obviouslyas compared with normal group, but there was no difference between 2 AC groups (P>0.05).It was suggested tnat the serum endotoxin level and mortality of AC during the early stage would be reduced remarkably with Rhubarb treatment.