四氧嘧啶致大鼠糖尿病与脂类过氧化

Alloxan-Induced Diabetes and Lipid Peroxidation in Rats

四氧嘧啶致SD大白鼠糖尿病的过程中,首先引起体内多种组织器官广泛发生脂类过氧化作用。脂类过氧化物分解产生一些醛类物质,故血清、胰腺、肝和肾组织中TBA反应物(主要成分为丙二醛)含量升高;生成的其它醛类物质与蛋白质结合形成的水溶性荧光物质含量亦增多。抗氧化剂维生素E的抗脂类过氧化作用对机体起保护作用;而维生素C在大量氧化剂四氧嘧啶存在的条件下起氧化强化剂的作用,并使机体对维生素E的消耗增多。

In the process of inducing diabetes in ratsby alloxan,lipid peroxidation (LPO)was initiated in many tissues.The lipid peroxides were catabolised into many aldehydes. The contents of TBA reactants (mostey malondialdehyde)in the serum, pancreas, liver and kidney homogenates were increased. The other aldehydes might combine with proteins to form the water-soluble fluores cent substances which were also increased in these tissues. Antioxidant vitamin E(VE) can protect against LPO. In the presence of high concentration of the oxidant alloxan, vitamin C(VC) acts as a prooxidant, and mere VE is consumed.