非容积依赖性呼吸力学参数估计的敏感度分析

SENSITIVITY ANALYSIS OF VOLUME-INDEPENDENT PULMONARY MECHANICAL PARAMETER ESTIMATION

研究呼吸运动过程中呼吸驱动压P(t)、呼吸气体流率V(t)及肺容积V(t)三者间的数量关系,建立相应数学模型,进而估计气道阻力(R_W)、肺顺应性(C_L)等呼吸力学参数,不仅有重要理论意义,并且在临床医学、环境医学等领域也有重要应用价值。一、呼吸力学模型呼吸过程中,胸膜腔压力相对于口腔压力的变化与呼吸气体流率。

To eliminate the effect of lung volume on the measurements of pulmonary mechanical parameters, two nonlinear models of pulmonary mechanics have been developed. Simulation study and sensitivity analysis indicated that a) estimates of lung elastic parameters were more precise than that of airway resistance parameters, b) appropriate combinaton of different operating points of lung volume and respiratory frequencies increased the ability to obtain well-determined parameter estimates. The models were demonstrated using the measurements of the respiratory flow rate and esophageal pressure during a deep inspiratory maneuver in 8 healthy male subjects.The volume-independent parameters in the models were estimated by a least square fitting procedure. In comparison with other models, the models reported in this paper seem to be more resonable and the method of parameter estimation is simple.