静注和静滴米氏消除动力学参数估计

ESTIMATION OF PHARMACOKINETICS PARAMETERS FOR INTRAVENOUS INJECTION AND INTRAVENOUS INFUSION IN MICHAELIS-MENTEN TYPE ELIMINATION AND PARALLEL FIRST-ORDER AND MICHAELIS MENTEN TYPE ELIMINATION

在非线性药物动力学中,Michaelis-Menten消除动力学(以下简称米氏动力学)和一级并行米氏动力学是最常见的两种,本文就这两种情况,给出一种估计静注和静滴动力学参数的方法——替换法。

The method to estimate pharmacokinetics V_m,k_m, is given for model of intravenous injection in Michaelis-Menten type elimination. A simulate comparision shows that the method has advantages over other method to estimate v_m,k_m.By substitution, the method can be spread to estimate parameters for model of intravenous injection and intravenous infusion in parallel first-order and Michaelis-Menten type elimination, the model is Michaelis-Menten type elimination when k=0.