摘要
本文在细菌视紫红质构象模拟的基础上提出了一个视黄醛顺反异构模型.该模型中视黄醛的C_(13)—C_(14)与Lys—216的C~δ—C^e处于一直线上,这样,顺反异构只涉及视黄醛C_(15)和Lys—216的N~ζ绕此直线为抽的旋转.理论计算表明,这是一种空间障碍最小的模型,并能通过Asp—96和Asp—212传递质子.
A model of trans 13-cis isomerization of Retinal in BR is proposed based on conformational simulation for BR. In this model, C13-C14 of Retinal can be in line with Cb-C4 of Lys-216, thus the isomerization will mainly concern the rotation of C15 and N4 two atoms. The model shows That Asp-96 and Asp-212 can play the role of proton donor and acceptor respectively. This model is in agreement with experimental observations and our calculations indicate that its position hindianc is minimal.
出处
《生物物理学报》
CAS
CSCD
北大核心
1989年第3期293-297,共5页
Acta Biophysica Sinica
