霉变甘蔗对神经组织的损伤──临床与病理

Ultrastructure Studies on Caudate Nucleus in Toxic Cerebropathy

变质甘蔗中毒是因食用霉变甘蔗而引起中枢神经系统损伤的一种中毒性疾病，主要发生在我国北方各省，发病急剧，病情凶险，预后危重，死亡率高。引起甘蔗霉变的病原菌能产生强烈的嗜神经毒素。本文观察了霉变甘蔗中毒性脑病患者神经组织活检标本的光学显微镜及电镜下的病理变化。观察结果提示，病理变化复杂，各种细胞成分均有不同程度损坏，主要表现为神经元固缩，胶质细胞变性、坏死，血管结构破坏，髓鞘损伤尤为突出。超微病理证实该病以神经组织的破坏性变化为主，后遗症期还伴有慢性反应性的病理变化。初步讨论了引起该病的中毒机理。

n this paper,we reported a ultrapathological changes of caudate nucleus of toxic cerebropathy.It iscaused by eating mildewed sugarcane.The specimen is gotten from the operation of brain transplantation.we found that the tissue of caudate nucleus have a damage in varying degrees. The major histopatholo-gical appearance are degeneration and necrosis of neuron and oligodendroglia as well as the destruction ofmyelin sheath and capillary.Our work first described the ultrapathological changes of the toxic cerebropathy in detail.This observa-tion provided a pathological basis for further research on this disease.Here we have discussed the toxic mech-anism of 3-Nitropropionic acid.