大骨节病区粮食中一种可疑真菌毒素的污染情况及其化学结构研究

Contaminative Condition and Chemical Structure of a SuspiciousMycotoxin in Cereal Harvested in Districts of Kashin-Beck Disease

本文用以ＥＣＤ－气相色谱仪测定丁烯酸内酯（Ｂｕ）的方法检测了大骨节病病区产的玉米、白面、小麦、青稞共１７２份。检出了一种与Ｂｕ的ＧＣ峰值保留时间相同的物质。经质谱测定表明，它是与Ｂｕ构造不同的物质。其红外光谱图与豆生丝核菌产生的流涎胺（Ｓｌａｆｒａｍｉｎｅ）真菌毒素的谱图相似。其确实的结构、来源及与大骨节病发病关系，有待进一步探究。

y epidemiological investigation in the districts of Kaschin-Beck disease,it is found that pathogenic factorcausing Kashin-Beck disease mainly exists in cereal food Of these districts and therefore l72 samples of maize,wheat flour,wheat & highland, barley from Kashin-Beck disease areas are examined with the method for deter-mination of butenolide(Bu ) by gas chromatography with electron capture detector (ECD-GC).A substancewith GC peak appeared at the same retention time as the Bu reference substance is detected. The detectionrates from 53 samples of maize and 34 samples of wheat flour are 84.9%&76.5%respectively. But,the de-tection rates from 45 samples of wheat and 40 samples of highland barley,both of which are unprocessed toflour, respectively merely 6.7%&17.5% dentification by mass spectrography shows that the suspicioussubstance is a diifferent matter from Bu. Its irifrared spectrogram is very much similar to that of slaframineproduced by Rhizoctonia leguminicola. Its conclusive structure,origin and relation to the etiology of Kashin-Beck disease are remained to be studied further.